TC-3 bioreactor
The TC-3 Bioreactor has been designed as a simple, easy-to-use system suitable to create cell culture experimental set-ups accounting for user-defined mechanical loading profiles. The needs of researchers who would like to culture cells under mechanical stimuli have been accounted for in the design of the TC-3. It combines the features of a traditional testing machine with the particular demands of cell culture, with special emphasis on the sterilization of the parts which are going to contact the culture medium, the easy assembling, the sample inspection by microscopy techniques and the straightforward sample manipulation.
Overview
The TC-3 permits to work with:
- Horizontally and vertically arranged multiple samples.
- Immersed and air-liquid interface setups.
- Sheet-shaped, rod-shaped and cylinder-shaped substrates.
- Tension and compression axial loading.
- Simultaneous flow and deformation conditions.
- Hydrostatic pressure conditions.
Depending on the scaffold type, it is also possible to use microscopy techniques to inspect the status of the culture in-situ.
Scalability and versatility are key features of the TC-3, in which three grips models can be interchanged in order to adapt to the features of the testing substrate or scaffold.
The system is controlled by a simple computer interface which allows defining the most common loading profiles which can be applied on the culture substrate.
Specifications
TC-3 Bioreactor technical sheet
| TC-3 Mechanical Stimulation Bioreactor | |
|---|---|
| Actuation system | |
| Dimensions [W x D x H] |
|
| Number of chambers | Up to 3 |
| Minimal displacement increment | 0.005 mm |
| Maximal force | 400 N |
| Control | PC-based control software |
| Power supply and consumption | 110-220 V, 50-60 Hz, IEC 14 power cord |
| Maximal deformation rate | 10 mm/s |
| Tension and Compression Chambers | |
| Autoclavable | Yes |
| External dimensions [W x D x H] | 78 x 137 x 51 mm |
| Internal dimensions [W x D x H] | 38 x 65 x 32 mm |
| Maximal internal volume [*] | ~ 90 ml |
|
|
| Autoclavable | Yes |
| Useful width | 35 mm |
| Maximal displacement | 31 mm |
| Minimal displacement | 1 mm |
|
|
| Autoclavable | Yes |
| Useful width | 30 mm |
| Maximal displacement | 30.5 mm |
| Minimal displacement | 0.5 mm |
|
|
| Autoclavable | Yes |
| Useful diameter [mm] | 22 mm |
| Maximal displacement [mm] | 30.5 mm |
| Minimal displacement | 0.5 mm |
| Tension-Compression and Flow Chambers | |
| Autoclavable | Yes |
| External dimensions [W x D x H] | 78 x 137 x 51 mm |
| Internal dimensions [W x D x H] | 38 x 65 x 32 mm |
| Maximal internal volume [*] | ~ 90 ml |
|
|
| Autoclavable | Yes |
| Scaffold diameter | 1.65 to 6.35 mm |
| Maximal displacement | 23 mm (for the 1/16″ connector) |
| Minimal displacement | 0 mm |
|
|
| Autoclavable | Yes |
| Maximal scaffold diameter | 10, 13 and 18 mm |
| Maximal displacement | 25 mm |
| Minimal displacement | 0 mm |
| Hydrostatic Pressure Chamber | |
| Autoclavable | Yes |
| External dimensions [W x D x H] | 80 x 137 x 83 mm |
| Internal dimensions [W x D x H] | 40 x 45 x 46 mm |
| Internal volume | ~ 80 ml |
| Maximal pressure | 4 bar |
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